The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study
Identifieur interne : 008653 ( Main/Exploration ); précédent : 008652; suivant : 008654The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study
Auteurs : Malcolm J. West [Australie] ; Paul J. Nestel [Australie] ; Adrienne C. Kirby [Australie] ; Renate Schnabel [Allemagne] ; David Sullivan [Australie] ; R. John Simes [Australie] ; Christine Pollicino [Australie] ; Edith Lubos [Allemagne] ; Thomas F. Münzel [Allemagne] ; Harvey D. White [Nouvelle-Zélande] ; Andrew M. Tonkin [Australie] ; Christoph Bickel [Allemagne] ; Laurence Tiret [France] ; Stefan Blankenberg [Allemagne]Source :
- European Heart Journal [ 0195-668X ] ; 2008-04.
Abstract
Aims We sought to determine the association between two major biomarkers, the inactive N-terminal fragment of brain natriuretic peptide (NT-proBNP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and long-term cardiovascular outcomes in a cohort of subjects who had a myocardial infarction or unstable angina 3–36 months previously. Methods and results Plasma NT-proBNP and TIMP-1 were measured in a nested case control study of 250 randomly matched subject pairs enrolled in the long-term intervention with pravastatin in ischaemic disease (LIPID) and LIPID extended follow-up studies. Cases (n = 250) were defined as those who had a cardiovascular death, non-fatal myocardial infarction or stroke during the studies. Controls (n = 250) remained event-free for the same follow-up duration (average 2.5 years) as the matched cases. The relationships between cases and plasma NT-proBNP and TIMP-1 were adjusted for the LIPID risk score, treatment allocation and other biomarkers (CRP, IL-6 and white cell count), and examined using a multivariable conditional logistic regression model. NT-proBNP levels were significantly higher in the cases than in the controls [389 (152–864) vs. 198 (93–416) pg/mL, median (25%–75% percentiles), P < 0.001]. The odds ratio (OR) of recurrent cardiovascular events in individuals in the highest quartile was three times higher than those in the lowest quartile (95% confidence interval (CI) 1.8–5.1; P < 0.001). Similarly, TIMP-1 levels were significantly higher among cases compared with controls (806 vs. 736 pg/mL, median: highest vs. lowest quartile: OR 2.8, 95% CI 1.6–4.7; P < 0.001). After adjustment for the LIPID risk score, treatment with pravastatin and other biomarkers, both NT-proBNP and TIMP-1 predicted cardiovascular events significantly and independently of each other. Conclusion The study suggests that in subjects with stable ischaemic disease, NT-proBNP and TIMP-1 are independent predictive markers of coronary heart disease outcome.
Url:
DOI: 10.1093/eurheartj/ehn007
Affiliations:
- Allemagne, Australie, France, Nouvelle-Zélande
- Nouvelle-Galles du Sud, Victoria (État), Île-de-France
- Melbourne, Paris, Sydney
- Université de Sydney
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Münzel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1, Mainz 55131</wicri:regionArea><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Green Lane Cardiovascular Service, Auckland City Hospital, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Tonkin, Andrew M" sort="Tonkin, Andrew M" uniqKey="Tonkin A" first="Andrew M." last="Tonkin">Andrew M. Tonkin</name><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>National Heart Foundation, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bickel, Christoph" sort="Bickel, Christoph" uniqKey="Bickel C" first="Christoph" last="Bickel">Christoph Bickel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Innere Abteilung, Bundeswehrzentralkrankenhaus, Koblenz</wicri:regionArea><wicri:noRegion>Koblenz</wicri:noRegion><wicri:noRegion>Koblenz</wicri:noRegion></affiliation></author><author><name sortKey="Tiret, Laurence" sort="Tiret, Laurence" uniqKey="Tiret L" first="Laurence" last="Tiret">Laurence Tiret</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U525, Faculte de Medecin Pitie-Salpetriere, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Blankenberg, Stefan" sort="Blankenberg, Stefan" uniqKey="Blankenberg S" first="Stefan" last="Blankenberg">Stefan Blankenberg</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1, Mainz 55131</wicri:regionArea><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation><affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation></author></analytic><monogr></monogr><series><title level="j">European Heart Journal</title><idno type="ISSN">0195-668X</idno><idno type="eISSN">1522-9645</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-04">2008-04</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="923">923</biblScope><biblScope unit="page" to="931">931</biblScope></imprint><idno type="ISSN">0195-668X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0195-668X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Aims We sought to determine the association between two major biomarkers, the inactive N-terminal fragment of brain natriuretic peptide (NT-proBNP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and long-term cardiovascular outcomes in a cohort of subjects who had a myocardial infarction or unstable angina 3–36 months previously. Methods and results Plasma NT-proBNP and TIMP-1 were measured in a nested case control study of 250 randomly matched subject pairs enrolled in the long-term intervention with pravastatin in ischaemic disease (LIPID) and LIPID extended follow-up studies. Cases (n = 250) were defined as those who had a cardiovascular death, non-fatal myocardial infarction or stroke during the studies. Controls (n = 250) remained event-free for the same follow-up duration (average 2.5 years) as the matched cases. The relationships between cases and plasma NT-proBNP and TIMP-1 were adjusted for the LIPID risk score, treatment allocation and other biomarkers (CRP, IL-6 and white cell count), and examined using a multivariable conditional logistic regression model. NT-proBNP levels were significantly higher in the cases than in the controls [389 (152–864) vs. 198 (93–416) pg/mL, median (25%–75% percentiles), P < 0.001]. The odds ratio (OR) of recurrent cardiovascular events in individuals in the highest quartile was three times higher than those in the lowest quartile (95% confidence interval (CI) 1.8–5.1; P < 0.001). Similarly, TIMP-1 levels were significantly higher among cases compared with controls (806 vs. 736 pg/mL, median: highest vs. lowest quartile: OR 2.8, 95% CI 1.6–4.7; P < 0.001). After adjustment for the LIPID risk score, treatment with pravastatin and other biomarkers, both NT-proBNP and TIMP-1 predicted cardiovascular events significantly and independently of each other. Conclusion The study suggests that in subjects with stable ischaemic disease, NT-proBNP and TIMP-1 are independent predictive markers of coronary heart disease outcome.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Nouvelle-Zélande</li></country><region><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="West, Malcolm J" sort="West, Malcolm J" uniqKey="West M" first="Malcolm J." last="West">Malcolm J. West</name></noRegion><name sortKey="Kirby, Adrienne C" sort="Kirby, Adrienne C" uniqKey="Kirby A" first="Adrienne C." last="Kirby">Adrienne C. Kirby</name><name sortKey="Nestel, Paul J" sort="Nestel, Paul J" uniqKey="Nestel P" first="Paul J." last="Nestel">Paul J. Nestel</name><name sortKey="Pollicino, Christine" sort="Pollicino, Christine" uniqKey="Pollicino C" first="Christine" last="Pollicino">Christine Pollicino</name><name sortKey="Simes, R John" sort="Simes, R John" uniqKey="Simes R" first="R. John" last="Simes">R. John Simes</name><name sortKey="Sullivan, David" sort="Sullivan, David" uniqKey="Sullivan D" first="David" last="Sullivan">David Sullivan</name><name sortKey="Tonkin, Andrew M" sort="Tonkin, Andrew M" uniqKey="Tonkin A" first="Andrew M." last="Tonkin">Andrew M. Tonkin</name></country><country name="Allemagne"><noRegion><name sortKey="Schnabel, Renate" sort="Schnabel, Renate" uniqKey="Schnabel R" first="Renate" last="Schnabel">Renate Schnabel</name></noRegion><name sortKey="Bickel, Christoph" sort="Bickel, Christoph" uniqKey="Bickel C" first="Christoph" last="Bickel">Christoph Bickel</name><name sortKey="Blankenberg, Stefan" sort="Blankenberg, Stefan" uniqKey="Blankenberg S" first="Stefan" last="Blankenberg">Stefan Blankenberg</name><name sortKey="Blankenberg, Stefan" sort="Blankenberg, Stefan" uniqKey="Blankenberg S" first="Stefan" last="Blankenberg">Stefan Blankenberg</name><name sortKey="Blankenberg, Stefan" sort="Blankenberg, Stefan" uniqKey="Blankenberg S" first="Stefan" last="Blankenberg">Stefan Blankenberg</name><name sortKey="Lubos, Edith" sort="Lubos, Edith" uniqKey="Lubos E" first="Edith" last="Lubos">Edith Lubos</name><name sortKey="Munzel, Thomas F" sort="Munzel, Thomas F" uniqKey="Munzel T" first="Thomas F." last="Münzel">Thomas F. Münzel</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Tiret, Laurence" sort="Tiret, Laurence" uniqKey="Tiret L" first="Laurence" last="Tiret">Laurence Tiret</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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